The correct answer to this open question is the following.
You forgot to include the question. Here we just have a statement.
If it is a "true" or "false" question, then the correct answer is "true."
If you need a commentary, here it is.
White American settlers who traveled to the west met fierce opposition from the Native American Natives of the region. The Native American Indians thought that those lands were theirs. The land belonged to them and had been inherited by their ancestors. That is why they defended their territories.
On the other hand, white settlers were interested in occupying those territories to settle in and exploit the many natural resources and raw materials of the region.
So as your statement reads, settlers and tribes both had effects on each other. On many trails headed west, settlers traveled in fear of attack from tribes who would rob or kill members of caravans. Tribes would attack stagecoaches and wagons that traveled across their lands. On the other hand, settlers constantly encroached on tribes' lands.