Answer: The impact was most severe in the Caribbean, where by 1600 Native American populations on most islands had plummeted by more than 99 percent. Across the Americas, populations fell by 50 percent to 95 percent by 1650. The disease component of the Columbian Exchange was decidedly one-sided.
Explanation:
The answer is a. Hope this helps.
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Answer:
I think the answer is new technology
The railroad boosted the economic status of the USA the transportation of raw materials and manufactured good to and from industries became faster and easier after the completion of the railroad