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Answer:
Spanish flu.
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While the Bubonic plague caused a far more painful death, the Spanish Flu caused far more deaths.
The "Middle Ages" or medieval period generally refers to the entire time span between classical antiquity and the modern era in Western history. The Middle Ages lasted approximately AD 500 - 1500, from the fall of the (Western) Roman Empire to the fall of the Byzantine Empire and the discovery and colonization of the New World. The Middle Ages are often partitioned into the Early, High, and Late Middle Ages.
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Frederick William (German: Friedrich Wilhelm; 16 February 1620 – 29 April 1688) was Elector of Brandenburg and Duke of Prussia, thus ruler of Brandenburg-Prussia, from 1640 until his death in 1688. A member of the House of Hohenzollern, he is popularly known as "the Great Elector" (der Große Kurfürst) because of his military and political achievements. Frederick William was a staunch pillar of the Calvinist faith, associated with the rising commercial class. He saw the importance of trade and promoted it vigorously. His shrewd domestic reforms gave Prussia a strong position in the post-Westphalian political order of north-central Europe, setting Prussia up for elevation from duchy to kingdom, achieved under his son and successor.
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