At the peak of the Roman Empire's reach, around A.D. 117, the Empire stretched as far north as modern Scotland, stretched down through Europe east into Asia as far as the border between modern day Iraq and Iran, with its southern reaches extending into northern Africa.
The Privileges and Immunities clause is addressed in the 14th amendment of the Constitution, which posits that no State shall make or enforce any law which shall abridge the privileges or immunities of citizens of the United States.