In Act IV, Scene III, when Macduff learns of his family's slaughter, he reacts with sorrow and grief. He talks about the grief that "does not speak," and states that his heart is breaking. He also feels guilty; he thinks his family was killed because of his actions, not their own
Methinks already from this chemic flame, I see a city of more precious mould: Rich as the town which gives the Indies name, With silver paved, and all divine with gold.