Sahaptin nations came into direct contact with whites several decades before the arrival of the members of the American Board of Commissioners for Foreign Missions (ABCFM). These relations set expectations among the Cayuse for how exchanges and dialogue with whites would operate. Primarily the early Euro-Americans engaged in the North American fur trade and the Maritime fur trade. Marine captains regularly gave small gifts to indigenous merchants as a means to encourage commercial transactions. Later land-based trading posts, operated by the Pacific Fur Company, the North West Company and the Hudson's Bay Company, regularized economic and cultural exchanges, including gift giving. Interactions were not always peaceful. Native Americans suspected that the whites had power over the new diseases that they suffered. Reports from the period note that members of the Umpqua, Makah, and Chinookan nations faced threats of destruction through white-carried illnesses, as the natives had no immunity to these new infectious diseases.[4] After becoming the premier fur gathering operation in the region, the HBC continued to develop ties on the Columbian Plateau.
"Article III. With regard to Southeastern Europe attention is called by the Soviet side to its interest in Bessarabia. The German side declares its complete political disinterestedness in these areas."
