Italy was not a unified nation in the 1500's but a series of regions and city-states which shared the same peninsula in the Mediterranean Sea. The power/domination of the Church of Rome had lost influenc.
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when trade routes shifted it lost its monopoly on trade in the east. War and foreign domination left it weak and divided
Answer: All-encompassing sectional differences on the issue of slavery, such as outright support/opposition of slavery, economic practices, religious practices, education, cultural differences, and political differences kept the North and South at near constant opposition to one another on the issue of slavery.
I think that what you're looking for is Manifest Destiny, the idea that it was natural, required and proper of the settlers to expand across the continent.
Some connected this to God (that is, that God devised this expansion as His plan), but God is not always necessarily connected to this idea.
I don't understand the question
