To give you a little background, the 5th century was a time period where the roman empire had two kings. One to rule the west and the other to rule the east. This made it easier to oversee the entire land. (Rome was the biggest empire ever recorded.) By the end of the 5th century, though, western Rome had fallen to the hands of their enemies while the eastern part held their ground. Anyways, during the 6th century the overthrow of the roman monarchy took place, they vowed to never let another king rule over Rome again. Eventually a dictatorship resulted.
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Bakke, 438 U.S. 265 (1978)
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In the longer term, the rise of Turkish power in Anatolia eventually gave rise to the Ottoman Empire which rapidly conquered the former Byzantine heartland over the course of the 14th and 15th centuries, culminating in the Fall of Constantinople to the army of Sultan Mehmed the Conqueror in 1453.
Transcontinental railroad and the bessemer process