The main impact on the Americas from the Colombian Exchange was how many Indigenous people were killed. The exchange transferred European diseases, such as syphilis, smallpox, mumps, chicken pox, and the flu, to the Americas (which native people had not experienced). Many died as a result of a lack resistance or cures to these new diseases.
In ancient times learned how to obtain copper from the ore by heating the rock to the metal melting point. They used to mould bronze objects by pouring the metal into stone shapes or ingots.