I'd say pollution or disease.
Answer:New France, French Nouvelle-France, (1534–1763), the French colonies of continental North America, initially embracing the shores of the St. Lawrence River, Newfoundland, and Acadia (Nova Scotia) but gradually expanding to include much of the Great Lakes region and parts of the trans-Appalachian West.
Explanation:
One of the major reasons why the attack of the Byzantine Empire by the Turks was significant that when the Turks initially attacked the Byzantine Realm, the Holy Lands which were also in the empire were overrun. <span>This lead to Alexius I asking the Pope for Christian knights to help him in the Crusades which then lead to Pope Urban II to allow the Crusades to happen.</span>
