If this is how you've presented the question, Its a bit hard to answer it when one hasn't read these books. It'd be best if you'd put both books into a summary for us to go based off of, at most.
The most dangerous game is about spirits exiting the spirit realm and poses you
The Mrs. Piggle-Wiggle series is about a small woman who lives in an upside-down house in a lively neighborhood inhabited mainly by children who have bad habits. Mrs. Piggle-Wiggle has a chest full of magical cures left to her by her deceased husband, Mr. Piggle-Wiggle, who was a pirate.