The 18th Amendment prohibited the sale of, the transportation of, the manufacturing of any alcoholic beverage. It did have the effect of enforcing a decline in deaths related to alcohol, but it did not entirely fulfill its intent.
Crime increased. Criminal activity increased. Al Capone became one of the richest man in America from the proceeds of black market alcohol. His 100K in the 20s would make his net worth about 18 billion in today's dollars.
The 18th became law in 1919. It was repealed in 1933 just 4 years later. It is the only amendment that suffered this fate.
It was the My Lai Massacre. This was when 24 U.S. soldiers
killed more than 500 civilians including men, women and children. It was said to be most shocking incident of
the war and generated international outrage due to the brutality of the
killings committed there.