Answer:
70 is the answer negative one begins from 83 and count down to 89, Therefore, 70 is is -4 and is chosen as the best answer
Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
Explanation:
Answer: Column F
Explanation: In Microsoft excel, for the sake of robustness and to aid the effectiveness of updating formulas across cells. The reference of cells are treated as relative which means that when formulas are copied across columns or within rows, they get updated automatically. However, some numbers may be treated as constants such that we do not want them to change or be updated as we move acisss cells. Thus, such numbers are treated Given absolute references, which is made possible by adding a '$' prefix before the colum alphabet or row number or both. in the scenario given above, the row has the $ prefix, hence, it is absolute and will not change but the column alphabet does not and hence, treated as relative.
Answer:
Operating systems now use networks to make peer-to-peer connections and also connections to servers for access to file systems and print servers. The three most widely used operating systems are MS-DOS, Microsoft Windows and UNIX.
Explanation:
