Most isolationists felt that there was no need for americans to feel threatened by developments in Europe and Asia because the vast pacific and atlantic oceans insulated the country from troubles in those regions, and the United States had formed friendly alliances with all the other nations in the Western hemisphere.
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Oddly enough, it wasn't Rome. Nor was it Antioch or Cordoba (both of those cities aren't even in Italy).
When the Byzantine empire expanded its borders under Justinian, it reclaimed much of what used to be part of the Roman Empire throughout the Mediterranean. But when they took Italy, they made Ravenna a provincial capital - not Rome. Later, it would eventually become the capital of a Byzantine Exarchate.
