Answer:
Correct answer is the Eastern Mediterranean and Middle East.
Explanation:
First option is not correct as Venice wasn't opened towards the Atlantic Ocean and actually lost its influence when the New World was discovered.
Second option is also not correct as the connection to this countries went through Atlantic Ocean.
Third option is also not correct for more or less the same reason and because Venice focused on maritime trade, which means that they didn't trade much with them as they as this countries are located in Central Europe.
Because its the largest city in its country or its region
Because there have been many invasions the correct answer would be C. The invasions would have brought many different ethnic groups into the area.