Question

imagine that there are mutations in the cdk genes such that their gene products are nonfunctional. what effect would this mutation have on an immature unspecialized blood cell precursor found in the bone marrow?

Answer 1

The mutations of the CDK genes in an immature unspecialized blood cell precursor would produce that the cell would NOT be able to reproduce itself. These genes control the cell cycle.

The cell cycle can be divided into two major stages: interphase, which is in turn divided into G1, S and G2 phases, and mitotic (M) phase.

Cyclin-dependent kinases (CDKs) and cyclins (their molecular partners) are proteins that control the progression through the different stages of the cell cycle.

CDKs are protein kinases that phosphorylate different protein substrates, thereby triggering molecular cascades associated with the progression of the cell cycle.

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