Answer:
No, laboratory information should be complemented with data related to the disease (e.g., symptoms of the viral disease) and patient' history (i.e., risk of exposure or close contact who were diagnosed with the disease)
Explanation:
In the last years, laboratory diagnosis of viral diseases has greatly improved and current methods (e.g., RT-PCR) have often a high sensitivity, thereby patients with this type of disease usually are accurately diagnosed clinically. However, there exist certain diseases where this information may not be conclusive. In these cases, it is imperative to use different sources of information to complement decision-making. For example, when laboratory diagnosis is not conclusive, the information provided by clinical symptoms of the disease in patients with severe acute respiratory syndromes (e.g., congestion and cough with or without fever in the first few days) can be very useful in order to determine if the infection is of viral origin or caused by bacterial types of pneumonia. Moreover, epidemiological data related to the recent life history of the patient (i.e., recent travel or residence in an area with viral transmission) can also be used for effective decision making.
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In the intervention group, 212 women (5.7 per 10,000 person-years) and 176 (4.7 per 10,000 person-years) received an ovarian cancer diagnosis (rate ratio [RR], 1.21; 95% confidence interval [CI], 0.99-1.48).
In the intervention group, there were 118 ovarian cancer-related deaths (3.1 per 10,000 person-years), compared to 100 in the standard care group (mortality RR, 1.18; 95% CI, 0.82-1.71).
1080 of the 3285 women who had false-positive test results underwent surgical follow-up, and 163 of them (15%) had at least one significant consequence.
Except for ovarian, colorectal, and lung cancer, there were 2924 deaths from other causes (76.6 per 10 000 person-years) in the intervention group and 2914 deaths (76.2 per 10 000 person-years)
Simultaneous screening with CA-125 and transvaginal ultrasound in comparison to standard treatment did not lower ovarian cancer mortality among women in the general US population. Complications were linked to diagnostic examination after a false-positive screening test result.
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