Question

Examine the flow chart above depicting the job of a gene known as p53. It plays an important role during the G2 checkpoint of cell cycle regulation. In 4-6 sentences, explain why p53 is often called "The Guardian of the Genome". Is p53 an oncogene (a gene that stimulates the growth of cancer cells) or a tumor suppressor gene (a gene that turns off the growth of cancer cells)? Explain your reasoning.

Answer 1

The p53 protein is known as the guardian of the genome because this protein prevents errors during DNA replication. It is a tumor suppressor gene.

Tumor suppressor genes

Tumor suppressor genes are genes that play fundamental cellular roles and prevent cell uncontrolled growth.

A tumor suppressor gene can repair errors that occurred during DNA replication, slow down the cycle of cell division, trigger programmed cell death, etc.

The p53 acts to control cell division and cell death, thereby avoiding the emergence of cancer cells.

Learn more about tumor suppressor genes here:

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