Answer and Explanation:
Native Indians in the Southeast, Southwest and Northeast resisted spanish influence in their respective territories. In addition, the mid-Atlantic Algonquians, and the Iroquoians of Huronia also resisted spanish influence.
In particular, the Southeast Indians had their first contact with Spanish explorer Hernando de Soto and his expedition during a time when most of the natives were farmers, and war had not yet been experienced in the Southeast region.
Initially, the Southeast Indians treated de Soto and his expedition very well by providing them with many gifts. However, de Soto and his expedition took this good treatment as a sign of weakness, and forced the natives (Southeast) into slavery.
Not long after this incident, information spread to other native Indians about their enslaved relatives; from that time onwards, the natives started mobilizing resistance against the spanish expedition's influence and slavery.
The natives kept up their resistance by repeatedly attacking de Soto and his expedition. Native warriors resisted spanish influence by constantly harassing the Spanish expedition in many battles.
