Statements 2, 3, and 5 are the correct modifications to control chromatin remodeling.
Any covalent addition of a chemical group to a histone through procedures like acetylation, methylation, ubiquitination, phosphorylation, etc. is referred to as a histone modification.
A histone protein's histone tail is modified by adding an acetyl group through the process of histone acetylation. Acetylation lessens the electrostatic interaction between DNA and histone proteins. As a result, the nucleosomal DNA is made visible by the opening up of the chromatin structure. The transcription machinery of the cell can access the DNA more easily as a result, which enhances gene transcription.
DNA methylation is the process of changing the cytosine bases in DNA into 5-methylcytosine by adding a methyl group. DNA methylation causes genes to become inactive and lowers gene expression.
A more open conformation of chromatin is produced as a result of histone phosphorylation, which gives the histone a negative charge. It plays a major role in transcription, DNA repair, chromosome condensation, and cell death.
Therefore, increasing DNA methylation and decreasing acetylation and phosphorylation of histones help to control the control chromatin remodeling.
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