The mechanoreceptor that is located deeper in the skin and responds continuously to stimulation and is associated with perceiving stretching of the skin is called Ruffini corpuscle.
Mechanoreceptor is a sensory receptor that responds to mechanical pressure. They are connected with sensory neurons that convert this mechanical pressure into electrical signal. It is of four types-
1. Merkel corpuscles- detect pressure and roughness on skin.
2. Ruffini corpuscles- detect deep tension in skin, skin stretch.
3. Meissner corpuscles- perception of light touch and slip on skin.
4. Pacinian corpuscles or Vater-panician corpuscles- detect rapid vibrations.
When these receptors sense a stimuli they gets excited and generates an impulse that travels through the nerve cells into the brain.
To learn more about Mechanoreceptor here
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Ans.
The first pass effect is defined as a phenomenon of metabolism of drug, in which drug concentration is greatly decreased before reaching the systemic circulation. It represents that fraction of drug lost, at the time of absorption of drug in gut.
Thus, the client is not receiving all the dosage of ingested drug (aspirin) because of the 'first pass effect.'
