This is a descriptive essay.
So much is at stake in writing a conclusion. This is, after all, your last chance to persuade your readers to your point of view, to impress yourself upon them as a writer and thinker. And the impression you create in your conclusion will shape the impression that stays with your readers after they've finished the essay.
Like others noted, this is a really vague question. I’ll assume you mean exceptionally brilliant or exceptionally beautiful.
Honestly, all four categories sound like a curse. I think the level of both intelligence and beauty most suited to happiness is a few notches above average. Extreme endowments usually turn into psychological baggage.
Obviously, being ugly - especially an ugly woman - is miserable. Feeling unattractive almost always equates feeling inferior. On the other hand, for many exceptionally beautiful women- especially for those who are “stupid” - their identity is almost entirely comprised in their physical appearance. The problem is that beauty is much more ephemeral than other traits. When those women hit 25, they have a small identity crisis, because that’s the age where physical bloom stops and your skin quality deteriorates. Age 30 is a huge crisis. And 40? I know (ex?)-beauties who don’t even know who they are by then.....lol there you go beautiful