These are all disadvantages but I would say that A and D or A and B are the most serious ones.
One of the main differences that can be seen is that cardiac muscles are involuntarily controlled, whereas the somatic nervous system controls the ovement of the skeletal muscles
Prokaryotic: before nucleus, no membrane bound organelles, and single celled microscopic organisms
eukaryotic: true nucleus, has membrane bound organelles, and multi cellular or unicellular organisms
therefore it would be letter <span>B. cell membrane and cytoplasm</span>
reproduction, heredity, variation in fitness or organisms, variation in individual characters among members of the population.