According to Boccaccio, some people believed the sins of some to be the cause of the plague. They believed that God punished them for committing sins by giving them the plague
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The painting shows the insignificance of one man's death.
He was used to being made fun of.
We know this by him taking this reply in ‘with a sort of humble patience’. This means that he has experienced this kind of teasing - or even bullying before and he is used to it.