Neuroleptic malignant syndrome
Antipsychotic medication can cause the neuroleptic malignant syndrome (NMS), a potentially fatal idiosyncratic reaction that is marked by fever, altered mental state, muscular stiffness, and autonomic dysfunction.
It has been linked to almost every neuroleptic, including more recent atypical antipsychotics, as well as a number of other drugs that influence central dopaminergic neurotransmission.
NMS is a rare condition, but it should still be taken into account when making a differential diagnosis for individuals who have fever and mental status changes since it has to be caught early to avoid serious morbidity and mortality.
The offending agent must be stopped right away, supporting measures must be put in place, and in more serious situations, pharmaceutical treatments may be necessary.
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