Answer:
1. d.water comes "out of" or "exits" the reaction
2. a.energy goes "into" or "enters" the reaction
3. Path A
Explanation:
1) Peptide bond synthesis is dehydration reaction which means water is "dehydrated" meaning released when the reaction occurs.
2) Anytime we want to join things together we gotta use energy, these processes are anabolic reactions such as making sugars, proteins, lipids, in our cell. Since we are making protein here, we need to put energy into the reaction.
3) Path A is hydrophobic b/c they directly diffuse thru cell membrane to attach to intracellular receptor.
My best attempt, hope its right.