Opinion or bias can cause the outcome of an experiment to be incorrect because it’s based off of a personal preference. That being said, any desirable outcome can be produced. One example of this would be human reproduction. Let’s say a person of Cuban race wants a mixed child. They would decide not to marry a Cuban spouse because it’s biased that the offspring will be only one race. Therefore, they would marry a person of a different race to provide a desirable outcome, which in this case, would be a biracial child. Bias leans a result toward one side, preferably the result desired. That’s how opinions and biases can cause the outcome of experiments to be incorrect.
One thing that happened between 1025 and 1076 was the schism between the Byzantine Orthodox Church and the Latin Church of Rome. This occurred in 1054. It was partly theological over the Filioque clause which was inserted by the Latin Church into the Nicene creed which was considered unauthorised by the Byzantines.