Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
D. Word roots contain the basic meaning of the
term.
Explanation:
Answer: health information management; information technology
Explanation:
<em>With the increase in electronic health records, more professionals are working in </em><em><u>Health Information Management</u></em><em>, which requires a familiarity with the healthcare system, as well as </em><em><u>Information technology.</u></em>
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The field of Health Information Management has seen a massive boost in recent years as more people train in this field which is necessary to input, analyze and protect the electronic health records of people.
Doing this job requires one to be well versed in both healthcare systems so that they have a familiarity with the data they are to manage, as well as information technology so that they can manage the electronic data.
A phobia is an irrational fear of something that's unlikely to cause harm. The word itself comes from the Greek word phobos, which means fear or horror
Prior to administering medication, the assessment the nurse will need to make is to take blood pressure measurements.
<h3>What is the function of the drug methylergonovine?</h3>
Methylergonovine is a drug which is used to prevent and control bleeding from the uterus that can happen after childbirth.
Methylergonovine belongs to the class of medicines called ergot alkaloids and works by acting directly on the smooth muscles of the uterus and prevents bleeding after giving birth.
Since bleeding results in decrease in blood pressure, prior to administering the medication, the nurse should assess the blood pressure of the patient by taking blood pressure measurements.
In conclusion, the drug methylergonovine is given to prevent bleeding after childbirth.
The patient's blood pressure measurement should be taken prior to administration of medication.
Learn more about blood pressure at: brainly.com/question/25149738
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