Answer:
The nullification crisis was a conflict between the U.S. state of South Carolina and the federal government of the United States in 1832–33. ... Calhoun, who opposed the federal imposition of the tariffs of 1828 and 1832 and argued that the U.S. Constitution gave states the right to block the enforcement of a federal law.
I am not 100% sure but I know it is not B. because I did the test myself but, he was a Southern Democrat so I personally would pick D. because that is the only one that seems fathomable.
One of the most important was climate changes. As climate changed, nomads had to find new places to migrate to which led to people going to areas that were uninhabited before. Another was the development of agriculture which more or less ended the nomadic way of life when people started settling.
The answer is income taxes