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Dvinal [7]
2 years ago
11

When doing medical research with human subjects, which four limitations are un voidable?

Biology
1 answer:
viva [34]2 years ago
6 0

The four limitations are

1.It's often impossible to repeat trials on the same subjects.

2-Subjects may report an inaccurate medical history.

3-It can be difficult to control all possible variables.

4-It's impossible to come up with testable scientific questions for human subjects.

Research involving human beings is ultimately necessary for improvements in human health and welfare. Any results about healthy physiology, illness causes, treatment effectiveness, learning, or behavior must be verified by carefully controlled investigations involving human participants. Sadly, not all human research have been valid and beneficial. It is possible to harm people in the name of research. The most well-known instances happened in Nazi Germany. Investigations conducted after the war found several crimes, including experiments in which participants were submerged in extremely cold water to determine how long it would take them to pass away from hypothermia.

Learn more about Medical research here

brainly.com/question/15215894

#SPJ10

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The values that most closely represent the expected number of Janice blonde-haired offspring is 252 individuals, option C.

Explanation:

<u>Available data</u>:

  • Two diallelic genes acting in a recessive epistatic manner to express hair color
  • Allele A is dominant over the allele a
  • Allele B is dominant over the allele b
  • A_B_ Cookie monster blue
  • aaB_ Elmo red
  • __bb Janice blonde

When talking about epistasis, we are referring to an interruption. These are interactions between genes located in different loci in the same chromosome. An epistatic gene can alter, influence, or suppress the expression of a hypostatic gene. When the epistatic gene is recessive, the interaction is known as <u>recessive epistasis</u>.  

Observing the altered phenotype proportions of the offspring can reveal which interaction is operating in the trait determination.  

In recessive epistasis, the proportion is 9:3:4.

Cross: Between two doubly-heterozygous

Parentals) AaBb    x    AaBb

Phenotype) Cookie-monster blue-haired individuals

Gametes)  AB, Ab, aB, ab

                 AB, Ab, aB, ab

Punnett square)     AB       Ab        aB         ab

                 AB      AABB    AABb  AaBB    AaBB

                 Ab      AABb    AAbb   AaBb    Aabb

                  aB     AaBB     AaBb   aaBB    aaBb

                  ab     AaBb      Aabb   aaBb    aabb

F1) 1000 individuals

     9/16 individuals are expected to be Cookie-monster blue-haired, A-B-

     3/16 individuals are expected to be Elmo Red, aaB-

     4/16 individuals are expected to be Janice blond, A-bb + aabb

16 ------------------------------------------- 1000 individuals

4 Janice blond individuals ---------- X = 250 individuals

So, 250 individuals are expected to be Janice blonde. The observed number might vary a little bit from this value.  The values that most closely represent the expected number of Janice blonde-haired offspring is c = 252 individuals

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