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The Renaissance was a rebirth of ancient Greek and Roman thinking and styles, and both the Roman and Greek civilizations were Mediterranean cultures, as is Italy. The best single reason for Italy as the birthplace of the Renaissance was the concentration of wealth, power, and intellect in the Church.
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Climate change that caused a severe drought.It is also theorized that the Hittite's cities were destroyed by earthquakes.
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Constantinople was the center of Byzantine trade and culture and was incredibly diverse. The Byzantine Empire had an important cultural legacy, both on the Orthodox Church and on the revival of Greek and Roman studies, which influenced the Renaissance.
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