Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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<span>B. He needs to take extra precautions when standing up because of possible orthostatic hypotension and resulting injury from falls.</span>
Answer:
Answer is C.
Explanation:
For A and B, a base substitution affects one of the three bases that comprise a codon, the DNA/RNA unit that corresponds to a particular amino acid. If one base is substituted, one codon and therefore one amino acid will be affected. Codons have built-in redundancy, so even by changing one base, the new codon sometimes still corresponds to the same amino acid. Therefore, a base substitution at most affects one amino acid, and sometimes doesn't affect it all.
Frameshift mutations cause a lot more trouble. These occur when you have a deletion or insertion that changes the number of bases in your gene. As a result, the "frame" of the codons changes (everything shifts one way or the other by the number of bases added/removed). This affects EVERY codon downstream of the mutation, so you can imagine that such a mutation would have a bigger effect the closer to the start of the gene it occurs. This is why C is correct.
Prokaryotes are single celled organism that lacks a membrane bound nucleus, mitochondria, or any other membrane bound organelle. Examples of prokaryotes include all single-celled organisms, most of which are bacteria. The principle ecological role of prokaryotes is to break down organic matter.
Answer:
1930s
Modern biodiesel fuel, which is made by converting vegetable oils into compounds called fatty acid methyl esters, has its roots in research conducted in the 1930s in Belgium, but today's biodiesel industry was not established in Europe until the late 1980s.
Explanation:
