Question

How does codominance at the molecular level help to explain why evolutionary processes haven't resulted in the elimination of the sickle-cell allele among people of African descent

Answer 1

Heterozygous individuals have both normal and sickle-cell hemoglobin in their red blood cells and reduced vulnerability to malaria.

What is codominance?

In terms of genetics, codominance is a sort of inheritance in which two distinct expressions (alleles) of the same gene result in distinct features in a person.

The expression of both alleles of a gene pair in a heterozygote is codominant. Offspring are produced as a result, and their phenotype is neither dominant nor recessive. According to the notion of incomplete dominance, this sort of inheritance happens when the phenotype is in between that of the parents and that of the child.

Red blood cells with the A antigen are represented by the IA allele, whereas red blood cells with the B antigen are represented by the IB allele. Since both the normal and sickled shapes can be seen in the blood, the allele is codominant in this way. Consequently, having two recessive alleles causes one to have type O blood.

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