Women with decreased numbers or function of a certain type of immune system cell experience pregnancy complications including im
1 answer:
Option C - T cells (Tregs) stand for regulatory T cells
Recent systematic studies have shown that Treg levels are significantly decreased in peripheral blood and decidua of pregnant and non-pregnant women with recurrent miscarriages (RM).
This underlines the hypothesis that Tregs play a role in the pathogenesis of RM. To ensure a robust placenta and sustainable pregnancy, an active state of tolerance on the level of immunity by Tregs is essential.
Survival of the allogeneic embryo in the uterus depends on the maintenance of immune tolerance at the maternal-fetal interface. The pregnant uterus is replete with activated maternal immune cells. How this immune tolerance is acquired and maintained has been a topic of intense investigation. The key immune cells that predominantly populate the pregnant uterus are natural killer (NK) cells.
In normal pregnancy, these cells are not killers, but rather provide a microenvironment that is pregnancy compatible and supports healthy placentation. In placental mammals, an array of highly orchestrated immune elements to support successful pregnancy outcomes has been incorporated. This includes active cooperation between maternal immune cells, particularly NK cells, and trophoblast cells.
Please check the attached file for the complete question.
Learn more about immune system cells at
#SPJ4
You might be interested in