The right answer is ghrelin levels are relatively low.
Ghrelin is a hormone secreted by the cells of the stomach, ghrelin triggers the sensation of hunger. The release of ghrelin is done when the body needs a new supply of energy and therefore to feed. The rate of ghrelin decreases following the meal: the hunger disappears.
This hormone is the subject of many studies: inhibiting its action may help to fight against obesity. At least for obesity due mainly to overeating.
A cladistic analysis shows the order in which derived characters evolved
The likely causes of the abnormal protein could be, both choice 1 and choice 2. Both are pretty similar in their consequence, since they describe a mutation which either keeps RNA polymerase to keep going after it usually stops or the stop codon, is not a stop site anymore. This causes are well documented and some of them are causes of illness. The third option, although feasible, it would find many obstacles, since introns would be hard to traduce. So, to sump up, choice 1 and choice 2 are the correct options.