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These are used as Potentiate pain relief.
Medications that might possibly affect painful symptoms including opioid analgesics, anticonvulsants , tricyclic antidepressants, capsaicin, benzodiazepines and skeletal muscle relaxants were gradually withdrawn during the study‐washout period. Paracetamol was allowed as rescue medication.
Tricyclic antidepressants are the most common type of antidepressant used for pain. These antidepressants inhibit the reuptake of serotonin and norepinephrine at the synapse, but do so differentially according to chemical structure.
<h3>How Antidepressants Work in Pain Management?</h3>
The explicit way in which antidepressants are effective in pain management remains unknown, but multiple mechanisms are likely to be involved.
Perhaps the most popular theory is that antidepressants exert their effects on serotonin and norepinephrine, particularly along the descending spinal pain pathways. Antidepressants may also exert adjunctive therapeutic influences through histamine receptors as well as modulation of sodium channels.
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Explanation:
The blank slate, the dominant theory of human nature in modern intellectual life stating that humans are shaped entirely by their experiences and not by any preexisting biological mechanisms, is being challenged and soundly trounced by the cognitive, neural, and genetic sciences, said Steven Pinker, Harvard University, in his Keynote Address.
“Everyone has a theory of human nature,” Pinker said. “Everyone has to anticipate the behavior of others, and that means all of us have theories, tacit or explicit, about what makes people tick.”
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Explanation:
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