Question

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

Answer 1

Tissue-Resident Memory (TRM) can be found in both CD4+ and CD8+ T cell lineages and in a variety of tissue locations.

What are resident memory T cells?

• Resident memory T cells are long-lasting, non-recirculating memory T cells found in epithelial barrier tissues such the gastrointestinal tract, lungs, skin, and reproductive tract.
• In line with a recent study that found memory T cells specific for persistent viruses in human tonsils, the predominance of TRM-phenotype cells in all human lymphoid tissues include the spleen, lymph nodes, and tonsils, and reflect their long-term persistence over decades and/or continual pathogen exposure.
• The cumulative encounter of different antigens over the course of a human lifetime may be the cause of TRM persistence in various places. The study of various diseases, from infection to cancer to inflammation and autoimmune disease, is becoming increasingly popular as a result of TRM.

Learn more about the Memory T cells with the help of the given link:

brainly.com/question/23423029

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