The asymmetric binding of citrate by the enzyme aconitase allows for asymmetric reactions of citrate in the citric acid cycle(TCA).
How does citrate behave during the TCA cycle?
Citrate synthase uses oxaloacetate and acetyl-CoA to create citrate in the Krebs cycle (CS). Citrate carrier allows for its export from the mitochondria (CIC). ACLY converts cytosolic citrate to acetyl-CoA and oxaloacetate. Fatty acid production can employ acetyl-CoA as a substrate.
What does the aconitase enzyme do?
Aconitase, also known as aconitate hydratase (EC 4.2.1.3), is an enzyme that catalyzes the non-redox-active process of stereo-specific conversion of citric acid(citrate) to isocitrate in the acid ( TCA ) cycle using cis-aconitate.
Therefore, option A is the correct choice.
Original question:
Citrate can react asymmetrically in the citric acid cycle because the enzyme aconitase
A) binds citrate asymmetrically.
B) binds either form of citrate.
C) binds both forms of isocitrate.
D) does not distinguish the -CH2COO- group.
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