1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
umka2103 [35]
2 years ago
8

Critical protein-protein interactions within the CARMA1-BCL10-MALT1 complex: Take-home points for the cell biologist

Biology
1 answer:
dolphi86 [110]2 years ago
4 0

Protein-protein interactions within the CARMA1-BCL10-MALT1 complex:

  • The T-cell receptor and B-cell receptor-dependent NF-B induction and lymphocyte activation are mediated by the CBM complex, which is made up of the proteins CARMA1, BCL10, and MALT1.
  • Each of the proto-oncoproteins CARMA1, BCL10, and MALT1 is a somatic gain-of-function mutation or chromosomal translocation, and dysregulation of CBM signaling is a characteristic of numerous lymphoid malignancies, including Activated B-cell Diffuse Large B-cell Lymphoma.
  • Moreover, a number of immunological dysregulation diseases have been linked to both gain- and loss-of-function germline mutations in CBM complex proteins.
  • Over the past ten years, careful examination of the interactions of CBM components has yielded a wealth of detailed structural knowledge.
  • Here, we discuss important discoveries about the molecular nature of these protein-protein interactions that have helped the research develop a detailed understanding of how these proteins come together to form high-order filamentous CBM complexes.
  • Approaches to therapeutic suppression of the CBM complex have thus far centered on obstructing MALT1 protease activity in order to treat lymphoid malignancy and/or autoimmunity.
  • The structural effects of MALT1 protease inhibitors on significant protein-protein interactions are also reviewed in detail.

To learn more about protein-protein interaction visit:

brainly.com/question/14573382

#SPJ4

You might be interested in
Which of the following is not a function performed by a membrane protein?
Reptile [31]

Enzyme synthesis cannot be a function performed by a membrane protein.

<u>Explanation:</u>  

Membrane protein is found on the lipid bilayer that surrounds the cell. Enzymes are the globular structures of proteins which are made by the translation of the specific m-RNA in the cytosol of the cell and not by the membrane proteins. While a membrane protein can be used as a pump to transport ions across the membrane, it can be used for cell-cell or cell-matrix adhesion and as a hormone binding protein.

4 0
3 years ago
A. Caudata B. Apoda C. Anura
kupik [55]

I dont really understand where someone would get this information. was there a document or article you were supposed to read before this if so that would be very helpful.  

6 0
3 years ago
An organism has the following traits:
exis [7]

Answer:

Archaea

Explanation:

Archaea is another term for Archaebacteria. also known as Bacteria which fits all the traits from the question.

5 0
4 years ago
What makes a fossil an index fossil ?
Masja [62]

Answer:

An index fossil is a fossil used to determine the age of the sediments in which it is found. When quickly approximating the age of new finds, an archaeologist looks at the rocks in which it is buried, as those sediments would have been on the surface at the time of the death of the pre-historic creature.

hope this helps

5 0
3 years ago
Read 2 more answers
John, a 19 year old boy, wanted to figure out why he wasn't sleeping well at night. He normally and heads to bed by 11 pm and wa
Katarina [22]

Answer:

The Pepsi he drinks at 10 pm

Explanation:

Pepsi is a caffeinated drink that has caffeine in it. Caffeine is a stimulant which means it keeps the body awake and alert. Caffeine works by mimicking adenosine. Adenosine is produced by neuron cells and when it binds to its own receptors (autocrine signaling) it triggers the neurons cells to continue firing. As the adenosine levels fall as the day progresses, the brain is signaled that it is time rest. Adenosine levels are at the lowest when its almost bedtime. However, when Jon takes Pepsi, the caffeine in it bind to the adenosine receptors and make the brain neurons to keep ‘firing’.

6 0
3 years ago
Other questions:
  • 3 steps of a nervous system reaction
    15·1 answer
  • Which of the following industries has not seen an increase in hazardous waste production?
    14·1 answer
  • Supposed that bill's genotype is (Hh) and his wife Sharon is (hh). What are the chances that his daughter, Grace, will also have
    9·1 answer
  • Fill in the blank
    15·2 answers
  • Where does spermatogenesis take place?<br> vas deferens<br> urethra<br> testes<br> penis
    11·2 answers
  • In a living organism, at which stage does segregation of gene pairs takes place?
    12·1 answer
  • Do you know the names of any of the body parts of a male or female reproductive system?
    9·2 answers
  • ⁉️‼️NEED answer ASAP‼️⁉️The pH of a solution is 7. Which best describes a solution? Solution has more hydrogen ions and hydroxi
    7·2 answers
  • Which statement describes a chemical property of sodium?
    13·2 answers
  • What process is responsible for creating magnetic changes along mid-ocean ridges
    11·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!