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umka2103 [35]
2 years ago
8

Critical protein-protein interactions within the CARMA1-BCL10-MALT1 complex: Take-home points for the cell biologist

Biology
1 answer:
dolphi86 [110]2 years ago
4 0

Protein-protein interactions within the CARMA1-BCL10-MALT1 complex:

  • The T-cell receptor and B-cell receptor-dependent NF-B induction and lymphocyte activation are mediated by the CBM complex, which is made up of the proteins CARMA1, BCL10, and MALT1.
  • Each of the proto-oncoproteins CARMA1, BCL10, and MALT1 is a somatic gain-of-function mutation or chromosomal translocation, and dysregulation of CBM signaling is a characteristic of numerous lymphoid malignancies, including Activated B-cell Diffuse Large B-cell Lymphoma.
  • Moreover, a number of immunological dysregulation diseases have been linked to both gain- and loss-of-function germline mutations in CBM complex proteins.
  • Over the past ten years, careful examination of the interactions of CBM components has yielded a wealth of detailed structural knowledge.
  • Here, we discuss important discoveries about the molecular nature of these protein-protein interactions that have helped the research develop a detailed understanding of how these proteins come together to form high-order filamentous CBM complexes.
  • Approaches to therapeutic suppression of the CBM complex have thus far centered on obstructing MALT1 protease activity in order to treat lymphoid malignancy and/or autoimmunity.
  • The structural effects of MALT1 protease inhibitors on significant protein-protein interactions are also reviewed in detail.

To learn more about protein-protein interaction visit:

brainly.com/question/14573382

#SPJ4

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4 years ago
How are RNA and DNA used to make proteins?
saw5 [17]

Answer:

The correct answer is<u> DNA has coded instructions for making proteins, and RNA translates the code.</u>  

Explanation:

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8 0
3 years ago
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Anna11 [10]
Geologists have known for about 100 years that the Earth is composed of four layers; the Crust, the Mantle, the Outer Core, and the Inner Core . 
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Because we can not go to the center of the earth we have to find our answers otherwise.

<span>This is what a geologist by the name of Andrija Mohorovicic did. He discovered in 1909 that earthquake waves near the surface moved slower than earthquake waves that passed through the interior of the Earth. He also noticed that the P (primary, first and strongest) waves that passed through the interior of the Earth did not do so in a straight line. These waves were bent or deflected by something! </span>
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<span>So by looking at the seismic waves from earthquakes the scientist learned about the crust and the mantle but they also learned about the outer and inner core. </span>
To do this you have to look at a different kind of waves, the S (secondary waves) waves that also get released by an earthquake. These S waves are slower.
<span>Beno Gutenberg , a German geologist, believed that the Outer Core must be made of a liquid because the slower S waves could not pass through this layer and in fact "bounced off" and were deflected many degrees off course. </span>
<span>The fourth layer, the Inner Core, is composed of very, very hot metals (iron and nickel) with pressures so great that the metals do not flow as a liquid, but are forced to vibrate in place like a solid. </span>
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Answer:

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Answer:

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Explanation:

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