Potent and Broad Neutralization of SARS-CoV-2 Variants of Concern (VOCs) including Omicron Sub-lineages BA.1 and BA.2 by Biparat

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2 years ago

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opic Human VH Domains

1 answer:

Evgesh-ka [11] · Answer 1 · 2023-11-09T20:16:33+03:00

Global health and economic development are still under danger due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.

What is variantion in SARS-CoV-2?

Variants of concern (VOCs) that have supplanted the original virus and turned into dominant strains around the world as a result of the dissemination of SARS-CoV-2 in global populations and adaptive evolution of the virus are now more common than the original strain.
The development of next-generation biologics with significant neutralizing breadth is necessary due to the rise of SARS-CoV-2 variants of concern (VOCs).
A human VH domain called F6 has been studied by scientists. It was created by progressively scanning sizable phage-displayed VH libraries against receptor binding domains (RBDs) with VOC mutations.
F6 has a distinctive binding mechanism that spans a large surface area of the RBD and involves the antibody framework region, according to cryo-EM investigations.
The construct (F6-ab8-Fc) that was created by joining an Fc region to the previously identified VH domains F6 and ab8 was effective at neutralizing a variety of VOCs, including Omicron.

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