Global health and economic development are still under danger due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
What is variantion in SARS-CoV-2?
Variants of concern (VOCs) that have supplanted the original virus and turned into dominant strains around the world as a result of the dissemination of SARS-CoV-2 in global populations and adaptive evolution of the virus are now more common than the original strain.
The development of next-generation biologics with significant neutralizing breadth is necessary due to the rise of SARS-CoV-2 variants of concern (VOCs).
A human VH domain called F6 has been studied by scientists. It was created by progressively scanning sizable phage-displayed VH libraries against receptor binding domains (RBDs) with VOC mutations.
F6 has a distinctive binding mechanism that spans a large surface area of the RBD and involves the antibody framework region, according to cryo-EM investigations.
The construct (F6-ab8-Fc) that was created by joining an Fc region to the previously identified VH domains F6 and ab8 was effective at neutralizing a variety of VOCs, including Omicron.
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