the differences between the Genain sisters in their experience of schizophrenia is de novo mutations in the fertilized egg or germ cells.
<h3>What is de novo mutations?</h3>
De novo mutations provide a mechanism for the persistence of early-onset reproductively lethal diseases in the population. These mutations, while individually rare, may account for a significant portion of the heritability for complex genetic diseases that genome-wide association studies cannot detect.
<h3>How do de novo mutations happen?</h3>
A genetic change that appears for the first time in one family member as a result of a variant (or mutation) in one of the parents' germ cells (egg or sperm), or a variant that arises in the fertilized egg itself during early embryogenesis. Also known as a de novo variant, new mutation, or new variant.
<h3>How many de novo mutations does a person have?</h3>
According to the findings, each person has approximately 70 de novo mutations that were not present in their parents' genetic code. Sasani et al. discovered that sperm and egg cells from older parents have more de novo mutations. This effect, however, varied significantly across Utah families.
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