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2 years ago

Clostridium difficile is a gram-positive, endospore forming anaerobe. Is endotoxin part of its virulence factor toolkit?.

Medicine

1 answer:

dem82 [27]2 years ago

3 0

No, endotoxin is associated with LPS, and <em>C. difficile</em> does not have LPS.

<h3>What are the endotoxins produced by <em>Clostridium difficile</em>?</h3>

A bacillus that produces toxins and forms spores, <em>Clostridium difficile</em> is Gram-positive and anaerobic. Once it enters the human intestine, <em>C. difficile </em>can transform into the disease-causing, vegetative condition. The presence of glycine and cholate derivatives makes this anaerobic bacterium well suited to the anaerobic environment of the colon, and it also makes <em>C. difficile</em> spore germination easier.

Toxin A (TcdA) and toxin B (TcdB) are the major endotoxins that regulate<em> Clostridium difficile's</em> pathogenicity. Target cells are largely affected by these toxins' disruption of their cytoskeletal framework and tight junctions, which results in rounding of the cell and eventual cell death. A fulminant illness is closely linked to detectable <em>C. difficile</em> toxemia. The development of <em>C. difficile</em> strains with toxin A and B gene mutations suggests that toxin B plays a significant role in the pathogenesis of CDI as a whole.

I understand the question you are looking for is this:

Clostridium difficile is a Gram-positive, endospore forming anaerobe. Is endotoxin part of its virulence factor toolkit?

a. yes, it produces several toxins.

b. no, endotoxin is associated with flagella, and <em>C. difficile</em> does not have flagella.

c. no, endotoxin is associated with teichoic acids, and <em>C. difficile </em>does not have teichoic acids.

d. no, endotoxin is associated with LPS, and <em>C. difficile</em> does not have LPS

Learn more about <em>Clostridium difficile </em>here:

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antiseptic1488 [7]

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2 years ago

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Andreas93 [3]

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2 years ago

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nikitadnepr [17]

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1 year ago

A practitioner order is written for an antimetic medication to be given IV 7.5mg Q 4 hours prn N/V. the medication is available

GaryK [48]

Answer:

1.5mL

Explanation:

This is 10mg/2mL, which simplifies to 5mg/1mL. To get 7.5mg, you need 1.5mL (multiple numerator and denominator by 1.5).

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3 years ago

In your opinion, whose professional role is it in healthcare to encourage patients to understand and take ownership of preventat

nataly862011 [7]

Answer:

By my reckoning, as a professional in healthcare, I'd answer your question that way:

Explanation:

All health professionals have a duty to provide this type of service, giving emphasis on preventive medicine since prevention will always be better than cure - better safe than sorry - but of course, it's clear that family doctors have much more opportunities to provide these kinds of service than those who have specialized areas.

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3 years ago