Yes, it is true that Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.
Focal malformations of cortical development, including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are important causes of intractable childhood epilepsy.
Using targeted and exome sequencing on DNA from resected brain samples and non-brain samples from 53 patients with FCD or HME, we identified pathogenic germline and mosaic mutations in multiple PI3K/AKT pathway genes in 9 patients, and a likely pathogenic variant in 1 additional patient.
Our data confirm the association of DEPDC5 with sporadic FCD but also implicate this gene for the first time in HME. Our findings suggest that modulation of the mammalian target of rapamycin pathway may hold promise for malformation-associated epilepsy.
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it forms covalent bonds by sharing electrons
Answer:
Explanation:
Deoxyribonucleic acid is said to contain instruction for species characteristics because it carries the information that characterize an individual.
DNA are made up of Nitrogenous bases that are unique codes specify by an individual and no two person has the same the DNA.
Genes are genetic information or instruction that specify an individual. it is located in the chromosome in the nucleus. DNA contains gene which helps to make molecules called proteins. It is the basis of all inheritance and the expression of the gene is what produces the phenotype that is visible.
Answer:
A
Explanation:
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The range of a set of data is the difference between the highest and lowest values in the set.
And to find the range, first order the data from least to greatest. Then subtract the smallest value from the largest value in the set.