individual research can vary greatly, but aggregated data from recent studies demonstrates that women with acute stroke are less likely than men to receive IV thrombolysis as treatment. However, compared to research released prior to 2008, the extent of this disparity has diminished.
Meta-analysis:
Objective: We updated our meta-analysis to see if the 30% gender difference in IV recombinant tissue plasminogen activator (rtPA) treatment for stroke still existed. The original meta-analysis was based on papers published between 2000 and 2008.
Methods: Between 2008 and 2018, we located papers that detailed sex-specific IV rtPA treatment rates for acute ischemic stroke. Research that used hospital-based, registry-based, or administrative data to compile representative populations of individuals with ischemic stroke qualified as studies. To measure sex differences, odds ratios (ORs) with random effects were created.
Results: Throughout this 10-year period, 24 studies that were qualified for inclusion were found. According to a summary unadjusted OR of 0.87 (95% confidence interval [CI], 0.82-0.93) based on data from 17 studies including all ischemic stroke patients, women had 13% lower odds than males of obtaining IV rtPA therapy. However, there was a sizable amount of between-study variation. Seven studies that provided information on the subset of patients eligible for IV rtPA treatment likewise found lower treatment odds in women, however the summary OR of 0.95 (95% CI, 0.88-1.02) was not statistically significant. 33 research that were published between 2000 and 2018 were examined for time patterns, and it was discovered that there was evidence that the gender gap had shrunk in more recent years.
Conclusions: The results of individual research can vary greatly, but aggregated data from recent studies demonstrates that women with acute stroke are less likely than men to receive IV thrombolysis as treatment. However, compared to studies released prior to 2008, the extent of this disparity has diminished.
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