Question

75-97% of beryllium-exposed workers who develop ________have a common HLA-DPB1 gene variant versus 30-45% of beryllium exposed workers who do not develop the disease

Answer 1

75-97% of beryllium-exposed workers who develop Chronic Berylliosis have a common HLA-DPB1 gene variant versus 30-45% of beryllium exposed workers who do not develop the disease.

Chronic berylliosis is a granulomatous disease caused due to beryllium exposure. Its symptoms include cough, fever, night sweats and fatigue.

The HLA-DPB1 gene belongs to a group of MHC genes called MHC class II. MHC class II genes provide information for synthesizing proteins that are present on the surface of certain immune system cells. These proteins attach to protein fragments or peptides outside the cell.

A definitive diagnosis of berylliosis is based on occupational history, positive blood or bronchoalveolar lavage (BAL) beryllium lymphocyte proliferation test (BLPT) and granulomatous inflammation on lung biopsy.

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