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Diano4ka-milaya [45]
2 years ago
7

How can databases of variants be used to help pinpoint a disease-causing mutation?

Biology
1 answer:
wel2 years ago
8 0

The human gene mutation database (HGMD) is a collection of published germ-line mutations in nuclear genes that underlie , or are closely associated with human inherited disease.

For identifying the pathogenic mutation among thousands to millions of genomic variant is a major challenges and prioritization strategies are required. Current strategies for Mendelian disease gene identification by exome re-sequencing.

Next generation sequencing (NGS) has been  used to identify new pathogenic mutations and genes causing rare genetic diseases.  The analyses of NGS data is not trivial and required a technically and biologically rigorous pipeline that address the data quality , accurate variant filtration to minimize mistakes.

To learn more about  pathogenic mutation here

brainly.com/question/20115738

#SPJ4

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All members of the plant kingdom contains chlorophyll? true or false
densk [106]

Answer:

this is true

Explanation:

if it isnt in the leaves of a plant, then its in the stem, or maybe, the entire thing is green!

flowers have green stems, trees have green leaves, lily pads are green, etc.

hope this helped

4 0
3 years ago
Read 2 more answers
How are hazards identified during mission planning?
Yuliya22 [10]
During mission planning, hazards are identified by the applying <span>mission, enemy, terrain, troops, time and civilians</span> framework.
This framework is usually referred to as METT-TC.
This framework is set to help military commander prioritize what they need to analyze during the planning of a mission.
Usually the civilian analysis is considered when the mission is to take place in an urban terrain.

4 0
3 years ago
Imagine that you've discovered a regulatory sequence thousands of base pairs away from the promoter and that when this sequence
Tresset [83]

Answer:

An Enhancer

Explanation:

Enhancers are the regulatory sequences and are generally located 80-160 base pairs upstream of the transcription start site. Enhancers have bidirectional elements that are involved in the initiation of transcription. Enhancers serve as the binding sites for activators to increase the concentration of activators in the vicinity of the promoter and thereby increase the rate of transcription of the gene.

According to the given information, the loss of a regulatory sequence led to a reduced level of transcription of the gene. This means that the regulatory sequence was involved in the upregulation of transcription. The presence of the sequence far away from the promoter makes it an enhancer.

4 0
3 years ago
In mitosis, two diploid daughter cells are formed. In other words, if you start with 46 chromosomes, you end up with 46 chromoso
svetlana [45]

Answer:

No

Explanation:

In mitosis you always end up with 4 daughter cells, althpugh it is true that theu start with 46 chromosomes and end up with 46 chromosomes.

8 0
3 years ago
Three components common to all amino acids
S_A_V [24]
Amino Group, Carboxyl Group, and the R group
4 0
3 years ago
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