Question

Activation of a g protein in response to hormone binding requires binding of _____ to the _____ subunit.

Answer 1

GTP must bind to the "α" subunit in order for a G protein to be activated as a consequence of hormone binding.

Discussion:

• Over 40 years ago, regulatory GTPases triggered by rhodopsin and beta-adrenergic receptors were initially identified as heterotrimeric G - proteins alpha subunits (G).
• The family's three prototypical members—Gs, Gi, and transducin (Gt), were purified and enzymatically described within ten years. Heterotrimeric G - proteins alpha subunits (G) are a distinctive type of Ras superfamily guanine nucleotide binding proteins22.
• The tertiary and quaternary shape, activation and signaling processes, and kinetic characteristics of G make them special. G subunits, like all other representatives of the Ras superfamily, consist of a six-stranded homologous core with helices connecting the majority of the strands in succession.

Therefore the correct choice is an option (A), i.e., GTP and α.

The complete question is:

Activation of a G protein in response to hormone binding requires binding of _____ to the _____ subunit.

A) GDP; B

B) GTP; a

C) GDP; Y

D) GTP; B

E) GDP; a

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