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marusya05 [52]
1 year ago
9

improved intravitreal aav-mediated inner retinalgene transduction after surgical internal limitingmembrane peeling in cynomolgus

monkeys
Biology
1 answer:
coldgirl [10]1 year ago
5 0

Because it is easily accessible and has a mild immune response, the retina makes a good target for gene therapy.

  • In a mouse model, the inner retina was highly effectively transduced by an intravitreally injected adeno-associated virus (AAV) vector.
  • The vitreous and internal limiting membrane (ILM) operated as obstacles to transduction in large animals, reducing the efficacy of retinal transduction.
  • Before administering AAV vectors, we performed vitrectomy (VIT) and ILM peeling on cynomolgus monkeys to get around these obstacles.
  • The findings suggest that surgical ILM peeling prior to AAV vector delivery would be beneficial for retinal disease treatment and safe for effective transduction of the nonhuman primate retina.

Learn more about the adeno-associated virus (AAV) with the help of the given link:

brainly.com/question/28205495

#SPJ4

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If something is burned a reaction has occurred <br><br>​
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Answer:

true

Explanation:

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How does the amount of energy emitted by a "warm blooded" animal compare to that from a "cold blooded" animal?
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The mutation that causes sickle cell disease in humans is
IgorC [24]

Answer: Missense mutation

Explanation:

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Hyaluronic acid fillers may be longer-lasting than previously described: A case report of delayed filler-associated facial cellu
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The most popular injectable augmentation product is a hyaluronic acid-based filler because it is more effective and safe than other injection fillers. Although the problem of infected filler is well established, it is unclear how long the filler will last before being absorbed. A case of hyaluronic acid-based filler-exacerbated facial cellulitis that occurred 2.5 years after filler administration was presented.

<h3>What are Injectable filler ?</h3>

Injectable filler is a soft tissue filler that can be injected into the skin at various depths to smooth out facial wrinkles, add volume to the face, and enhance facial characteristics.

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Learn more about Injectable filler here:

brainly.com/question/4455725

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