jochmanova i, yang c, zhuang z, pacak k. hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right

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2 years ago

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direction. j natl cancer inst. 2013;105(17):1270-83

1 answer:

Sveta_85 [38] · Answer 1 · 2023-07-05T20:12:52+03:00

An adrenal gland can develop an uncommon, often benign (noncancerous) tumor called a pheochromocytoma.

A (pseudo)hypoxic signature is seen in many solid tumors, such as paraganglioma (PGL) and pheochromocytoma (PHEO). It has been demonstrated that (pseudo)hypoxia encourages the development of tumors and therapeutic resistance.
Hypoxia-inducible factors (HIFs) are the main mediators of the transcriptional hypoxic response.
The transcription of hypoxia-responsive genes, which are involved in cancer, is induced by high levels of HIFs. Catecholamine-producing tumors called PHEOs and PGLs develop from sympathetically or parasympathetically generated chromaffin tissue.
HIF signaling appears to be crucial for the growth and development of PHEOs and PGLs, which may point to novel therapeutic strategies for the management of these malignancies.

Learn more about the pheochromocytoma with the help of the given link:

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