Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level is the main cause for heart failure.
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What are the main cause of Heart failure?</h3>
- Heart failure is mostly caused by interconnected pathways including fibrosis and inflammation. Understanding cell-type-specific disease in the failing human myocardium necessitates detailed understanding of gene expression perturbations and cell-cell interactions of leukocytes and non-myocytes.
- In order to achieve this, we sequenced 200,615 cells from human hearts with dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) using single-cell RNA sequencing and single T cell receptor sequencing. To capture the cellular and molecular changes to various degrees of cardiac fibrosis, we sampled both lesion and mild-lesion tissues from each heart.
- For example, infarcted (lesion) and non-infarcted area (mild-lesion) were dissected from ICM hearts, whereas the left (lesion) and right ventricle (mild-lesion) of DCM hearts were harvested.
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The answer fam is...........80%
Digestion
The difficult process of digesting food into nutrients that the body utilizes for energy, development, and cell repair is known as digestion. Along with producing trash to be expelled, digestion also produces garbage.
The digestive system, also known as the gastrointestinal tract, is a long, twisted tube that extends from the mouth to the anus. It is made up of several muscles that control the transport of food and added cells that make hormones and enzymes to help break down food. Other "accessory" organs like the liver and pancreas are also necessary for digestion along the route.
To be taken into the watery blood plasma, big, insoluble food molecules must be broken down into smaller, water-soluble food molecules during digestion.
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